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Contraindicated (one)pentobarbital will lessen the level or effect of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the extent or effect of avanafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. For sufferers with ED, check response cautiously because of po